Enzyme-Catalyzed Reactions of the Carcinogen N -Hydroxy-2-fluorenylacetamide with Nucleic Acid
Authors:
- 22 March 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3821) , 1351-1353
Abstract
A protein fraction obtained by gel filtration of a 105,000g supernatant of rat liver catalyzes three reactions of the hepatocarcinogen N -hydroxy-2-fluorenylacetamide with nucleic acid. Cofactor requirements and isotopic studies suggest that the reactive intermediates involved may be N -2-fluorenylhydroxylamine, and phosphate and sulfate esters of N -hydroxy-2-fluorenylacetamide.Keywords
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