Abstract
The disease Can the disease be clearly defined? Is the condition an important problem in terms of prevalence and incidence or morbidity and mortality? Is it a policy priority? Does the condition present a diagnostic problem (inaccuracy or inefficiency), and would it be useful to have better diagnostic tools? Is there evidence of current variation in diagnostic practice (or inappropriate variations in treatment, morbidity, or mortality resulting from diagnostic variability)? Could the diagnostic processing pathway for the disease be improved by obtaining information in a less risky fashion or in a manner more acceptable to patients?

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