The bone‐derived collagen containing mineralized matrix for the loading of collagen‐binding bone morphogenetic protein‐2

Authors:
Publisher website
Google Scholar
Abstract
Bone tissue‐derived biomaterials have often been applied for bone repair because of their similarity to human bone in structure and composition. When combined with growth factors, they could accelerate bone formation. Here, we explore a collagen containing mineralized bone‐derived matrix (CCMBM) from bovine bone tissues, which not only maintains proper mechanical strength but also binds to the collagen‐binding recombinant human collagen‐binding bone morphogenetic protein‐2 (CBD‐BMP2). By analyzing its morphology and composition, we found that CCMBM was porous and mainly composed of calcium compounds. CCMBM could provide mechanical support for bone injury repair. It also showed good biocompatibility and proper degradation rate that would be helpful for bone regeneration. In addition, the intentionally preserved collagen allowed the specific binding of CBD‐BMP2 to CCMBM, and resulted in significantly increased osteogenesis in vivo. The results indicated that the combination of CCMBM with collagen‐binding BMP2 could be emerged into an effective medical device for bone repair. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

This publication has 33 references indexed in Scilit: