Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells
Authors:
- I. L. CampbellICI. L. Campbell
- G. MorahanGMG. Morahan
- T. E. MandelTMT. E. Mandel
- L. C. HarrisonLHL. C. Harrison
- J. F. A. P. MillerJMJ. F. A. P. Miller
- 1 June 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 333 (6173) , 529-533
Abstract
A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic beta cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process.Keywords
This publication has 30 references indexed in Scilit:
- Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.Proceedings of the National Academy of Sciences, 1988
- T cell tolerance by clonal elimination in the thymusCell, 1987
- Multiple immunological abnormalities in patients with Type 1 (insulin-dependent) diabetes mellitusDiabetologia, 1987
- Function and Specificity of T Cell Subsets in the Mouse1987
- Germline and somatic mosaicism in transgenic miceDevelopmental Biology, 1986
- Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.Proceedings of the National Academy of Sciences, 1986
- Alternative protein products with different carboxyl termini from a single class I gene, H-2Kb.Proceedings of the National Academy of Sciences, 1986
- Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesNature, 1985
- Expression of major histocompatibility antigens on pancreatic islet cells.Proceedings of the National Academy of Sciences, 1981
- Breeding of a Non-Obese, Diabetic Strain of MiceExperimental Animals, 1980