Dually Cross‐Linked Supramolecular Hydrogel as Surface Plasmon Resonance Sensor for Small Molecule Detection

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Abstract
Dually cross‐linked supramolecular hydrogels (DCSH) are designed to show responsive properties while maintaining the gel structure by introducing two different kinds of cross‐links. This is realized by utilizing a photo‐cross‐linker for permanent cross‐linking and β‐cyclodextrin (β‐CD) and ferrocene (Fc) as host–guest recognition pair. The DCSH shows increased swelling in the presence of the small target molecule adamantane amine (Ada). Ada can break the non‐covalent bonding between β‐CD and Fc through competitive molecular guest interaction with β‐CD. By using a combination of surface plasmon resonance and optical waveguide spectroscopy, it is possible to use this behavior to construct a reversible sensor for specific small molecule detection.

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