Effect of Chronic Hypoxia on Angiotensin-lnduced Pulmonary Vasoconstriction and Converting Enzyme Activity in the Rat

Authors:
  • RCR. W. Caldwell
    R. W. Caldwell
  • CBC. M. Blatteis
    C. M. Blatteis
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Abstract
Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.