Safety and Toxicity of Oxamniquine in the Treatment of Schistosoma Mansoni Infections, with Particular Reference to Electroencephalographic Abnormalities

Authors:
  • SKSigmund Krajden
    Sigmund Krajden
  • JKJay S. Keystone
    Jay S. Keystone
  • CGCathie Glenn
    Cathie Glenn

Abstract
Thirty-seven patients infected with Schistosoma mansoni were treated with oxamniquine. All were cured. The only significant adverse reaction was the development of abnormal electroencephalographic (EEG) findings in 6 (17.6%) of 34 patients whose pretreatment EEG was normal. Management of patients, with particular reference to the EEG abnormalities, is discussed.

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