C-terminal domains of bacterial proteases: structure, function and the biotechnological applications

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Abstract
C‐terminal domains widely exist in the C‐terminal region of multidomain proteases. As a β‐sandwich domain in multidomain protease, the C‐terminal domain plays an important role in proteolysis including regulation of the secretory process, anchoring and swelling the substrate molecule, presenting as an inhibitor for the preprotease and adapting the protein structural flexibility and stability. In this review, the diversity, structural characteristics and biological function of C‐terminal protease domains are described. Furthermore, the application prospects of C‐terminal domains, including polycystic kidney disease, prepeptidase C‐terminal and collagen‐binding domain, in the area of medicine and biological artificial materials are also discussed.
Funding Information
  • National Natural Science Foundation of China (31070061, 31370104, 21205142)
  • National Sparking Plan Project (2013GA770009)
  • Opening Foundation of the Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution (2015CNERC-CTHMP-07)
  • Open-End Fund for the Valuable and Precision Instruments of Central South University (CSUZC201640)
  • Fundamental Research Funds for the Central Universities of Central South University (2015zzts273)

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