Comparision of Different Techniques Involved in the Development of Ivabradine HCL Floating Pulsatile Multiparticulate Systems for Chronotherapeutic Delivery

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Abstract
Aims: To develop Ivabradine HCl floating pulsatile multiparticulate (beads/ pellets) dosage forms containing calcium alginate beads/ pellets coated with pH-dependent polymer Eudragit S 100, by ionic gelation, pan coating, fluidized bed coating techniques and optimization of technique by comparing evaluation parameters with statistical data.