The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance

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Abstract
Accumulating evidence suggests that variants of concern (VOC) of SARS-CoV-2 evolve to evade the human immune response, with much interest focused on mutations in the spike protein that escape from antibodies. However, resistance to the innate immune response is essential for efficient viral replication and transmission.
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Funding Information
  • UKRI | Medical Research Council (MR/S000844/1)
  • UKRI | Medical Research Council (MR/N013700/1)
  • UKRI | Medical Research Council (MC_UU12014/2)
  • Wellcome Trust (WT098049AIA)
  • Wellcome Trust (206369/Z/17/Z)

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