SEXUAL DIMORPHISM AND THE EFFECTS OF THE X‐LINKED Tfm LOCUS ON HEXOBARBITONE METABOLISM AND ACTION IN MICE

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Abstract
Normal males of the testicular feminized strain of mice (Tfm) had longer hexobarbitone‐induced sleeping times than females, and hepatic hexobarbitone hydroxylase activity differed in that the Km was higher and the Vmax lower in the male Castration and androgen replacement studies indicated that testicular androgens were responsible for the sexual differences in drug metabolism found in this mouse strain Hepatic hexobarbitone metabolism and action were feminized in the intact, androgen‐insensitive, genetically male Tfm mouse. Furthermore, hexobarbitone hydroxylase activities were less responsive to large doses of testosterone in Tfm mice than in normal males The Tfm mouse with a deficiency in androgen receptors responded to the enzyme‐inductive effects of phenobarbitone and softwood bedding, indicating that these inducers do not act through the androgen receptors.

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