Dexmedetomidine-Induced Stimulation of Glutamine Oxidation in Astrocytes: A Possible Mechanism for its Neuroprotective Activity
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Open Access
- 1 June 2000
- journal article
- research article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 20 (6) , 895-898
Abstract
Dexmedetomidine is a highly specific α2-adrenergic agonist, which is used clinically as an anesthetic adjuvant and in animal experiments has a neuroprotective effect during ischemia. The current study showed that dexmedetomidine enhances glutamine disposal by oxidative metabolism in astrocytes. This effect occurs at pharmacologically relevant concentrations. It is exerted on α2-adrenergic receptors and not on imidazoline-preferring sites, and it is large enough to reduce the availability of glutamine as a precursor of neurotoxic glutamate.Keywords
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