Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors

This publication has 35 references indexed in Scilit:

• Inhibition of poly (ADP‐ribose) synthetase by gene disruption or inhibition with 5‐iodo‐6‐amino‐1,2‐benzopyrone protects mice from multiple‐low‐dose‐streptozotocin‐induced diabetes
  British Journal of Pharmacology, 2001
• The response of Parp knockout mice against DNA damaging agents
  Mutation Research - Reviews in Mutation Research, 2000
• Poly (ADP-ribose) polymerase, nitric oxide and cell death
  Trends in Pharmacological Sciences, 1999
• Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice
  Molecular and Cellular Biochemistry, 1999
• A dual approach in the study of poly (ADP-ribose) polymerase: In vitro random mutagenesis and generation of deficient mice
  Molecular and Cellular Biochemistry, 1999
• Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
  Nature Medicine, 1997
• Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
  Proceedings of the National Academy of Sciences, 1997
• The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
  Proceedings of the National Academy of Sciences, 1990
• Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA
  Journal of Molecular Biology, 1989
• Poly(ADP‐ribose) polymerase is a zinc metalloenzyme
  European Journal of Biochemistry, 1984