INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN

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Abstract
Intradermal injection of prostaglandin (PG) D1 and D2 in the human forearm produced a long‐lasting dose‐related erythema. When compared with prostaglandin E1 or E2 the order of potency for erythema production was PGE1 > PGE2 > PGD2 > PGD1. In rat skin, prostaglandin D2 but not D1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125I‐albumin extravasation technique. Prostaglandin E2 was 3–5 times more potent than prostaglandin D2. Prostaglandin D2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. Prostaglandin D2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan‐induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.

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