Circadian-induced hypothermia of the cerebral cortex in rehabilitation of patients after ischemic stroke

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Abstract
Introduction. The role of circadian (nocturnal) cerebral hypothermia in brain recovery following daytime activity is well recognized. The study aim is to investigate the clinical effects of craniocerebral hypothermia (CCH) administered in the evening in patients during the early post-stroke recovery period. Materials and methods. The study included 95 patients in the early recovery period after IS, of whom 70 comprised the main group and 25 — the comparison group. Patients in both groups received pharmacotherapy, physiotherapy (magnetotherapy, electrotherapy), therapeutic exercise, and massage. Treatment in the main group was supplemented with a course of CCH (10 daily sessions of 90 minutes each, administered between 20:00 and 22:00). Results. Patients in the main group showed significantly greater improvements in cognitive and motor functions, increased daily activity, and enhanced self-care ability and functional independence compared to the comparison group. In addition, patients in the main group showed improved sleep quality. Conclusion. This study indicates the feasibility of incorporating CCH into comprehensive rehabilitation programs for patients after IS, taking into account the physiological circadian rhythmicity of brain temperature changes, and provides a rationale for considering CCH as a nature-inspired (biomimetic) technology.

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