Diverse Causes of Hypoglycemia-Associated Autonomic Failure in Diabetes
- 27 May 2004
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 350 (22) , 2272-2279
Abstract
This review explains our current understanding of the syndromes of defective glucose counterregulation and hypoglycemia unawareness in persons with diabetes. The physiologic defenses against hypoglycemia — the glucagon and epinephrine responses — are compromised in most people with type 1 diabetes and in many with advanced type 2 diabetes. In addition to hypoglycemia, exercise and sleep are causes of autonomic failure that must be recognized and require changes in the management of diabetes.Keywords
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