Food safety remains a global concern for public health, economic stability, and society well-being. Mycotoxins, one of the most prevalent and severe classes of contaminants, are toxic secondary metabolites produced by filamentous fungi. Generally, the main mycotoxins are divided into aflatoxins (AF), ochratoxins (OT), fumonisins (F), zearalenone (ZEN), deoxynivalenol (DON), and T-2 toxin, thereby contaminating a wide spectrum of commodities like cereals, maize, peanuts, fruits, oil, milk, and processed foods. Of them, for instance, AFB1, OTA, FB1, ZEN are regulated as group 1, 2B, 3 carcinogens by International Agency for Research on Cancer (IARC), respectively. Considering their serious risks to animal and human health, many countries and organizations including European Union, USA, China etc., have set the maximum residue levels (MRLs) down to ppt levels toward mycotoxins in certain commodities.analytical methods, high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), represent for the gold standard against quantitative detection of mycotoxins. However, high cost, skilled personnel, and time-consuming procedures limit their application scenarios to laboratory. Fortunately, assisted by antibody development, antibody-based immunoassays like enzyme-linked immunosorbent assay (ELISA) and immunosensors have been well established for rapid and on-site food analysis. Nevertheless, several obstacles such as weak reproducibility, false-positive results and complicated protocols remain big challenge.Consequently, there is an urgent demand to exploit novel biosensing and chemosensing platforms that enable fast, sensitive, specific, cost-effective, and point-of-care (POC) testing of mycotoxins and even trace levels.Very excitingly, our research topic entitled "Advanced Biosensors and Chemosensors toward Mycotoxins Analysis for Food Safety" is timely and of high significance to food safety, conceiving to overcome the challenges by exploring cutting-edge sensing platform, elucidating the underlying mechanisms and design principles, and revealing their potential for commercialization. Upon the continuous efforts, accordingly, the collection attracts four contributions spanning original research and comprehensive review, advancing our knowledge of mycotoxin detection from molecular recognition to real-world monitoring (Figure 1).