Synthesis of drug-crosslinked polymer nanoparticles
Authors:
- 15 January 2015
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Polymer Chemistry
- Vol. 6 (10) , 1703-1713
Abstract
A new kind of drug-crosslinked polymer nanoparticle was prepared. The nanoparticles were composed of a phenylboronic acid modified hydroxycamptothecin crosslinker (HCPT-diHMPBA) and a 1,2-diol-rich poly(ethylene oxide)-b-poly(glycerol monomethacrylate) diblock copolymer (PEG-PGMA), and crosslinked by a phenylboronic ester bond. Dynamic light scattering measurement and electron microscopy observation revealed that the nanoparticles had a spherical morphology with a hydrodynamic diameter of 146 nm. The phenylboronic acid modified hydroxycamptothecin crosslinker could be released from the nanoparticles in a sustained manner and converted into pharmaceutically active hydroxycamptothecin (HCPT) in an enzyme-containing medium, as shown in the in vitro cytotoxicity test. Cellular uptake examination by confocal laser scanning microscopy showed that the nanoparticles were well internalized by cancer cells and active HCPT was found inside the cells.Keywords
This publication has 36 references indexed in Scilit:
- Thermoresponsive core–shell nanoparticles with cross-linked π-conjugate core based on amphiphilic block copolymers by RAFT polymerization and palladium-catalyzed coupling reactionsPolymer, 2014
- Camptothecin prodrug block copolymer micelles with high drug loading and target specificityPolymer Chemistry, 2014
- Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticlesJournal of Controlled Release, 2013
- pH-responsive and biodegradable polymeric micelles based on poly(β-amino ester)-graft-phosphorylcholine for doxorubicin deliveryPolymer Chemistry, 2013
- The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapyChemical Society Reviews, 2012
- Pathogen-mimetic stealth nanocarriers for drug delivery: a future possibilityNanomedicine: Nanotechnology, Biology and Medicine, 2011
- Disulfide Core Cross‐Linked PEGylated Polypeptide Nanogel Prepared by a One‐Step Ring Opening Copolymerization of N‐Carboxyanhydrides for Drug DeliveryMacromolecular Bioscience, 2011
- Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(ε-caprolactone) nanoparticles: Preparation and antitumor activity in vivoJournal of Controlled Release, 2010
- Optimization of (1,2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activityJournal of Controlled Release, 2007
- Structure and design of polymeric surfactant-based drug delivery systemsJournal of Controlled Release, 2001