Bifunctinoal Phosphonium Salt‐Catalyzed Asymmetric Cyclodearomatization of 2‐Nitroindoles and 2‐Nitrobenzofurans for Constructing CF3‐Containing Spiro‐Polycycles

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Abstract
An efficient enantioselective dearomative cycloaddition reaction between either 2‐nitroindoles or 2‐nitrobenzofurans and N‐2,2,2‐trifluoroethylisatin ketimines by dipeptided phosphonium salt catalysis is firstly established. This protocol provides a new and facile synthetic approach to create a variety of CF3‐containing polycyclic spirooxindole derivatives under mild reaction conditions with high yields in excellent diastereo‐ and enantioselectivities (all >20:1 dr, up to 95% ee). magnified image
Funding Information
  • National Natural Science Foundation of China (21971165, 21921002, 21801173)
  • Sichuan University

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