Superacid Catalyzed Hydroxyalkylation of Aromatics with Ethyl Trifluoro­pyruvate: A New Synthetic Route to Mosher’s Acid Analogs

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Abstract
A new superacid catalyzed Friedel-Crafts hydroxy­alkylation of aromatics with ethyl trifluoropyruvate is described. The trifluoromethanesulfonic acid or gallium(III) trifluoromethanesulfonate catalyzed reactions give α-hydroxy α-trifluoromethyl phenyl acetic acid ethyl ester and its derivatives (analogs of Mosher’s acid) in good yields for both highly activated hetero­aromatics and substituted benzenes.