Synthesis of Allenyl Ketones by the Palladium-Catalyzed Carbonylation of 2-Alkynyl Carbonates in the Presence of Soft Carbon Nucleophiles

Authors:
  • TMTadakatsu Mandai
    Tadakatsu Mandai
  • HKHiroaki Kunitomi
    Hiroaki Kunitomi
  • KHKiyoto Higashi
    Kiyoto Higashi
  • MKMikio Kawada
    Mikio Kawada
  • JTJiro Tsuji
    Jiro Tsuji
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Abstract
Palladium-catalyzed carbonylation of 2-alkynyl methyl carbonates 1 in the presence of active methylene and methine compounds 5 and sodium hydride proceeds smoothly under mild conditions to give allenyl ketones 6 in good yields.