Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase
Authors:
- 1 February 1991
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 273 (3) , 803-806
Abstract
We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5′-[beta gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.Keywords
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