Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing
- 1 June 2023
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 34 (7) , ar68
Abstract
It is demonstrated that neurofilament length and transport are regulated by a dynamic cycle of neurofilament polymer severing and end-to-end annealing. An enzymatic severing mechanism for neurofilaments involving N-terminal phosphorylation of their constituent polypeptides is proposed.Keywords
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