Isolation and Structure of the Human Cancer Cell Growth Inhibitory Cyclodepsipeptide Dolastatin 16,,1
Authors:
- 1 August 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (8) , 752-754
Abstract
An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high- field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipeptide exhibited strong inhibition of growth against a variety of human cancer cell lines.Keywords
This publication has 7 references indexed in Scilit:
- Dolastatin H and Isodolastatin H, Potent Cytotoxic Peptides from the Sea Hare Dolabella auricularia: Isolation, Stereostructures, and SynthesisJournal of the American Chemical Society, 1996
- The Dolastatins 20. A Convenient Synthetic Route to Dolastatin 15Tetrahedron, 1994
- Isolation of dolastatins 10–15 from the marine molluscTetrahedron, 1993
- The natural polypropionate-derived esters of the mollusk Onchidium spThe Journal of Organic Chemistry, 1992
- Antineoplastic agents. 224. Isolation and structure of neristatin 1Journal of the American Chemical Society, 1991
- Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell LinesJNCI: Journal of the National Cancer Institute, 1991
- Studies on the solution- and solid-state structure of patellin 2Journal of the American Chemical Society, 1990