Long-Term Expanding Porcine Airway Organoids Provide Insights into the Pathogenesis and Innate Immunity of Porcine Respiratory Coronavirus Infection

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Abstract
Porcine respiratory CoV (PRCoV), a natural mutant of TGEV, shows striking pathogenetic similarities to human respiratory CoV infection and provides an interesting animal model for human respiratory CoVs, including SARS-CoV-2. The lack of anin vitromodel recapitulating the complicated cellularity and structure of the porcine respiratory tract is a major roadblock for the study of PRCoV infection.
Funding Information
  • MOST | National Key Research and Development Program of China (2021YFD1801104)
  • MOST | National Key Research and Development Program of China (2021YFD1801105)
  • National Natural Science Foundation of China (32192453)
  • National Natural Science Foundation of China (32172865)

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