The clinical profile, hematological parameters and liver transaminases of dengue NS1 Ag positive patients admitted to Jaffna Teaching Hospital, Sri Lanka
Open Access
- 23 September 2019
- journal article
- research article
- Published by Springer Nature in BMC Research Notes
- Vol. 12 (1) , 1-5
Abstract
Objective: Objective of the study is to evaluate the on-admission day symptoms and signs, clinical, hematological parameters and liver transaminases of the dengue NS1 positive patients who got admitted on different clinical phases [Febrile phase (day 1–3) and Critical phase(day 4–5)] of dengue at medical wards of Jaffna Teaching Hospital.Results: Blood samples were collected from 150 suspected dengue patients from day 1 to 5 of the illness. Seventy-eight patients were positive for dengue NS1, according to the WHO proposed dengue clinical phase framework 37 patients were from febrile phase and 41 patients from critical phase. Patients who admitted on critical phase framework suffered from leukopenia and thrombocytopenia. Nine patients had the evidence of leakage with fever and the leakers had significant rise in hemoglobin, hematocrit and liver transaminase levels which are considered as severe form of the disease.Keywords
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Funding Information
- National Science Foundation of Sri Lanka (RPHS/2016/D02)
This publication has 14 references indexed in Scilit:
- Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective studyBMC Hematology, 2018
- Value of peripheral blood count for dengue severity predictionBMC Research Notes, 2018
- Dengue NS1 antigen as a marker of severe clinical diseaseBMC Infectious Diseases, 2014
- Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activationBlood, 2013
- A Three-Component Biomarker Panel for Prediction of Dengue Hemorrhagic FeverThe American Journal of Tropical Medicine and Hygiene, 2012
- Global Climate Change and Its Potential Impact on Disease Transmission by Salinity-Tolerant Mosquito Vectors in Coastal ZonesFrontiers in Physiology, 2012
- Association of platelet count and serological markers of dengue infection-importance of NS1 antigenIndian Journal of Medical Microbiology, 2011
- The NS1 Glycoprotein Can Generate Dramatic Antibody-Enhanced Dengue Viral Replication in Normal Out-Bred Mice Resulting in Lethal Multi-Organ DiseasePLOS ONE, 2011
- Dengue Virus Pathogenesis: an Integrated ViewClinical Microbiology Reviews, 2009
- Evaluation of Two New Commercial Tests for the Diagnosis of Acute Dengue Virus Infection Using NS1 Antigen Detection in Human SerumPLOS Neglected Tropical Diseases, 2008