An Electrochemical Detector for Liquid Chromatography with Picogram Sensitivity

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Abstract
A simple liquid chromatograph with an extremely sensitive electrochemical detector is described. The detector, which can be constructed for lees than $5.00 (excluding electronics), has an actual dead volume of < 1 μl and operates well in the 50–100 picogram region. Routine quantitative work at the 5–10 nanogram level is described. Potential applications to the analysis of biogenic amines are discussed.

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