Association of polymorphisms of genes encoding serotonin, dopamine, and noradrenergic neurotransmitter systems with parameters of night sleep and daytime sleepiness in adolescents

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Sleep disorders are common among adolescents and are associated with an increased risk of academic failure, affective disorders, and behavioral problems. Individual differences in sleep parameters are partly due to genetic factors, polymorphisms of genes of neurotransmitter systems involved in the regulation of the sleep-wake cycle. Objective. To analyze the associations of nighttime sleep parameters and daytime sleepiness with polymorphic regions of nine candidate genes of serotonin-, dopamine-, and noradrenergic neurotransmitter systems ( MAOA, HTR1A, HTR1A2, COMT, DRD2, DRD4, DBH, SLC6A4, SLC6A2 ) in Russian adolescents. Materials and methods.896 Caucasian adolescents aged 12-18 years (mean age 14.38±1.92 years, boys/girls 45.4%/54.6%) were examined. Nighttime sleep parameters were assessed using selected questions from the Pittsburgh Sleep Quality Index, and daytime sleepiness was assessed using the Pediatric Daytime Sleepiness Scale. Genotyping was performed by real-time polymerase chain reaction using TaqMan probes. Statistical analysis was performed using the SNPStats program with evaluation of various inheritance Results. models and calculation of odds ratios with 95% confidence intervals. A significant association was found between the T allele of the rs1137070 polymorphism of the monoamine oxidase A gene and extremely short nighttime sleep duration (less than 6 hours; odds ratio (OR)1.41; 95% confidence interval (CI) 1.091.81; p=0.008) and increased daytime sleepiness (OR 1.29; 95% CI 1.05-1.60; p=0.018). The T allele of the rs1800497 (TaqIA) polymorphism of the dopamine receptor D2/ANKK1gene demonstrated a protective effect against frequent nighttime awakenings (OR 0.69; 95% CI 0.52-0.92; p=0.0098). Conclusion. The established genetic associations indicate a significant contribution of heritable individual differences in the functioning of monoaminergic neurotransmitter systems to sleep regulation in adolescents.

This publication has 45 references indexed in Scilit: