Decoding of columnar-level organization across cortical depth using BOLD- and CBV-fMRI at 7 T

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Abstract
Multivariate pattern analysis (MVPA) methods are a versatile tool to retrieve information from neurophysiological data obtained with functional magnetic resonance imaging (fMRI) techniques. Since fMRI is based on measuring the hemodynamic response following neural activation, the spatial specificity of the fMRI signal is inherently limited by contributions of macrovascular compartments that drain the signal from the actual location of neural activation, making it challenging to image cortical structures at the spatial scale of cortical columns and layers. By relying on information from multiple voxels, MVPA has shown promising results in retrieving information encoded in fine-grained spatial patterns. We examined the spatial specificity of the signal exploited by MVPA. Over multiple sessions, we measured ocular dominance columns (ODCs) in human primary visual cortex (V1) with different acquisition techniques at 7 T. For measurements with blood oxygenation level dependent (BOLD) contrast, we included both gradient echo- (GE-BOLD) and spin echo-based (SE-BOLD) sequences. Furthermore, we acquired data using the vascular-space-occupancy (VASO) fMRI technique, which is sensitive to cerebral blood volume (CBV) changes. We used the data to decode eye-of-origin from signals across cortical layers. While ocularity information can be decoded with all imaging techniques, laminar profiles reveal that macrovascular contributions affect all acquisition methods, limiting their specificity across cortical depth. Therefore, although MVPA is a promising approach for investigating the mesoscopic circuitry of the human cerebral cortex, careful consideration of macrovascular contributions is needed that render the spatial specificity of the extracted signal.
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