Development of polyvinyl alcohol–gelatin membranes for antibiotic delivery in the eye

Authors:
  • ECEdmund Carvalho
    Edmund Carvalho
  • ABAjit Kumar Banthia
    Ajit Kumar Banthia
  • RBRinti Banerjee
    Rinti Banerjee
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Abstract
Aim: The aim of the present study was to develop biosynthetic hybrid polymer-based ocular insert for topical administration of antibiotics for treatment of ocular infections. Methods: Ciprofloxacin hydrochloride-loaded three different inserts were prepared by solution casting method by esterification of a biopolymer (gelatin) with a synthetic polymer (polyvinyl alcohol, PVA). Esterification between PVA and gelatin was confirmed by Fourier transform infrared spectroscopy. Results: Inserts were found to be wettable and swellable with simulated tear fluid and had a contact angle Conclusions: In brief, the study suggests that PVA–gelatin polymeric blends are promising as ocular inserts for prolonged release of antibiotic in the eye as compared to eyedrops. Such inserts may also be therapeutically beneficial for treatment of corneal ulcers and external ocular infections.

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