Stressresistenz durch Adaption der mitochondrialen Form

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Mitochondria are dynamic cellular compartments that can remodel their own shape and activity. They sense and convert cellular signals into informative triggers, allowing the cell to adapt to its ever-changing needs. We discovered that under stress this adaptation is performed by the E4 enzyme Ufd2/UBE4B, which tags mitochondrial fusion factors called mitofusins, thus signalling their degradation. Our findings highlight therapeutic intervention cues for mitofusin-associated diseases.

This publication has 13 references indexed in Scilit: