Comparision of The Efficiency of Ethacridine Lactate and Hypochlorous Acid During the Early Period of Wound Healing in Rats

Authors:
  • YAYehia Alhbou
    Yehia Alhbou
  • BKBirkan Karsli
    Birkan Karsli
  • TSTuğçe SÜMER
    Tuğçe SÜMER
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Abstract
The aim of this study was to compare between ethacridine lactate and hypochlorous acid on wound healing in rat wound model through clinical and histopathological studies. The rats were divided into three groups; group 1: Control group, group 2: Hypochlorous acid (HOCL) group, group 3: Ethacridine Lactate (EL) group. Each group contained seven animals. Under anesthesia, 20 mm full layer skin resection was performed from dorsal interscapular region. Wound sizes were measured with milimetric paper in 3rd, 7th and 14th days postoperatively. At the end of the 14th day, the animals were sacrificed under deep anesthesia and extensive skin resection including the wound area was performed and sent for histopathological examination. Macroscopic examination of wounds revealed that the wound was completely closed without the crust formation in the HOCl group, and also there was only a scar line in some animals of HOCL group at the end of 14th day. Mild inflammatory cell, intense fibroblast activity and the lowest SOD and GPx immunoreactivity were found in the HOCL group compared to the other two groups (P<0.05). Consequently, it was observed that wound healing was performed faster in animals treated with HOCl compared to EL and control group macroscopically and histopathologically.

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