The selective dopamineD3receptor antagonistSB‐277011Aattenuates drug‐ or food‐deprivation reactivation of expression of conditioned place preference for cocaine in male sprague‐dawley rats

Authors:
Publisher website
Google Scholar
Abstract
We determined the effect of the selective dopamine D3receptor antagonist SB‐277011A on reactivation of conditioned place preference (CPP) to cocaine elicited by priming injections of cocaine or exposure to food deprivation stress (21 h) in male Sprague–Dawley rats. Animals paired with the cocaine‐associated chamber displayed a robust and consistent CPP response. This CPP was extinguished after repeated pairings of the conditioned stimuli (cocaine‐paired chamber contextual cues) in the absence of the unconditioned stimulus (cocaine). Twenty‐four hours later, the administration of 5 mg kg−1i.p. of cocaine (immediately before the test) or exposure to 21 h of food deprivation reactivated the expression of the cocaine‐induced CPP. In contrast, administration of 1 ml kg−1i.p. of vehicle did not reactivate the CPP response. Administration of the selective dopamine D3receptor antagonist SB‐277011A (3–24 mg kg−1i.p.) 30 min before cocaine administration on the test day produced a significant attenuation of CPP reactivation. Reactivation of the CPP response produced by food deprivation was also significantly attenuated by SB‐277011A (6 or 12 mg kg−1i.p.) given 30 min before the test session. SB‐277011A (12 or 24 mg kg−1i.p.) did not itself produce reactivation of the CPP response. Overall, these results suggest that the reactivation of the incentive value of drug‐associated cues by cocaine or food deprivation is attenuated by selective antagonism of D3receptors.Synapse 69:336–344, 2015.

This publication has 66 references indexed in Scilit: