The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations
Open Access
- 16 October 2019
- journal article
- research article
- Published by American Society of Hematology in Blood Advances
- Vol. 3 (20) , 2949-2961
Abstract
Key Points: CMML monocytes exhibit a proinflammatory transcriptional signature, contributing to malignant expansion and increased cardiovascular risk.Keywords
This publication has 87 references indexed in Scilit:
- STAR: ultrafast universal RNA-seq alignerBioinformatics, 2012
- Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesisNature Genetics, 2012
- Bump hunting to identify differentially methylated regions in epigenetic epidemiology studiesInternational Journal of Epidemiology, 2012
- TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasmsBlood, 2011
- Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune responseNature Reviews Immunology, 2011
- Monocyte and Macrophage Dynamics During AtherogenesisArteriosclerosis, Thrombosis, and Vascular Biology, 2011
- Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansionProceedings of the National Academy of Sciences, 2010
- Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1Cell Stem Cell, 2010
- A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cellsBlood, 2008
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences, 2005