Maternal serum perlecan levels in women with preeclampsia
- 2 January 2020
- journal article
- research article
- Published by Taylor & Francis in Hypertension in Pregnancy
- Vol. 39 (1) , 70-76
Abstract
Objective: Perlecan is an extracellular matrix proteoglycan suggested to maintain endothelial functions. We aimed to measure maternal serum perlecan levels in different preeclampsia phenotypes. Methods: This study included 50 women with preeclampsia and 30 healthy pregnant women. Results: Serum perlecan levels were significantly higher (p = 0.016) in preeclamptic women with severe features(n = 23) than preeclampsia patients(n = 27). There were no statistically significant differences in serum perlecan levels between the early-onset preeclampsia(n = 25), late-onset preeclampsia(n = 25), and healthy pregnancies. Conclusion: Our findings suggest that preeclamptic women with severe features have higher serum perlecan levels than women with preeclampsia.Keywords
This publication has 37 references indexed in Scilit:
- The “Great Obstetrical Syndromes” are associated with disorders of deep placentationAmerican Journal of Obstetrics and Gynecology, 2011
- Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS modelThe Lancet, 2011
- Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsiaJournal of Perinatal Medicine, 2011
- Hypoxic regulation of secreted proteoglycans in macrophagesGlycobiology, 2009
- Early and Late PreeclampsiaHypertension, 2008
- Novel interactions of perlecan: Unraveling perlecan's role in angiogenesisMicroscopy Research and Technique, 2008
- Reduced perlecan expression and accumulation in human carotid atherosclerotic lesionsAtherosclerosis, 2007
- Altered perlecan expression in placental development and gestational diabetes mellitusPlacenta, 2005
- Severe Maternal Morbidity Associated with Hypertensive Disorders in Pregnancy in the United StatesHypertension in Pregnancy, 2003
- Developmental expression of perlecan during murine embryogenesisDevelopmental Dynamics, 1997