Hereditary Hemolytic Anemia with Triosephosphate Isomerase Deficiency

Authors:
  • ASArthur S. Schneider
    Arthur S. Schneider
  • WVWilliam N. Valentine
    William N. Valentine
  • MHMasao Hattori
    Masao Hattori
  • HHHenry L. Heins
    Henry L. Heins
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Abstract
THE demonstration of the association of inherited deficiencies of erythrocyte enzymes with certain congenital hemolytic anemias has aided a greater understanding of the genetic and pathological manifestations of these disorders, and has resulted in a more definitive classification of these heterogeneous conditions. In 1954 Selwyn and Dacie1 separated the congenital nonspherocytic hemolytic anemias into two classes, Types 1 and 2, on the basis of differences in the spontaneous autohemolysis of sterile defibrinated blood. Valentine, Tanaka and Miwa,2 , 3 in 1961, described the occurrence of a marked deficiency of erythrocyte pyruvate kinase in association with hemolytic disease classifiable as Type 2 on . . .