Coronary Serum Exosomes Derived from Patients with Myocardial Ischemia Regulate Angiogenesis through the miR-939-mediated Nitric Oxide Signaling Pathway
Open Access
- 1 January 2018
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 8 (8) , 2079-2093
Abstract
Rationale: Angiogenesis is a crucial step towards tissue repair and regeneration after ischemia. The role of circulating exosomes in angiogenic signal transduction has not been well elucidated. Thus, this study aims to investigate the effects of coronary serum exosomes from patients with myocardial ischemia on angiogenesis and to elucidate the underlying mechanisms.Keywords
This publication has 37 references indexed in Scilit:
- Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxationProceedings of the National Academy of Sciences, 2012
- miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytesProceedings of the National Academy of Sciences, 2012
- Hsp20 Functions as a Novel Cardiokine in Promoting Angiogenesis via Activation of VEGFR2PLOS ONE, 2012
- Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathwayFree Radical Biology and Medicine, 2012
- Nitric oxide synthases: regulation and functionEuropean Heart Journal, 2011
- Pre-processing and differential expression analysis of Agilent microRNA arrays using the AgiMicroRna Bioconductor libraryBMC Genomics, 2011
- Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell MigrationMolecular Cell, 2010
- Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cellsJournal of Cellular and Molecular Medicine, 2010
- High levels of circulating endothelial microparticles in patients with acute coronary syndromesAmerican Heart Journal, 2003
- Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.Journal of Clinical Investigation, 1994