Ubiquitin–Proteasome Pathway Function Is Required for Lens Cell Proliferation and Differentiation

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Abstract
Purpose. The ubiquitin proteasome pathway is involved in the regulation of many cellular processes, such as cell cycle control, signal transduction, transcription, and removal of obsolete proteins. The objective of this work was to investigate roles for this proteolytic pathway in controlling the differentiation of lens epithelial cells into lens fibers.