Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?
Authors:
- M UllaMUM Ulla
- S ThoboisSTS Thobois
- J-J LemaireJLJ-J Lemaire
- A SchmittASA Schmitt
- P DerostPDP Derost
- E BroussolleEBE Broussolle
- P-M LlorcaPLP-M Llorca
- F DurifFDF Durif
- 25 July 2006
- journal article
- case report
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 77 (12) , 1363-1366
Abstract
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.Keywords
This publication has 9 references indexed in Scilit:
- High-frequency stimulation in Parkinson's disease: more or less?Trends in Neurosciences, 2005
- Deep Brain Stimulation for Treatment-Resistant DepressionNeuron, 2005
- A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorderBipolar Disorders, 2004
- Mania following deep brain stimulation for Parkinson’s diseaseNeurology, 2002
- The neuropsychology and neuroanatomy of bipolar affective disorder: a critical reviewBipolar Disorders, 2001
- Transient Acute Depression Induced by High-Frequency Deep-Brain StimulationNew England Journal of Medicine, 1999
- Subgenual prefrontal cortex abnormalities in mood disordersNature, 1997
- I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: A clinical studyBiological Psychiatry, 1997
- Circuitry and functional aspects of the insular lobe in primates including humansBrain Research Reviews, 1996