FcγRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan
Open Access
- 13 March 2009
- journal article
- research article
- Published by Springer Nature in Malaria Journal
- Vol. 8 (1) , 43
Abstract
A SNP at position 131, in the FcγRIIa gene, affects the binding of the different IgG subclasses and may influence the clinical variation seen in patients with falciparum malaria. This study confirms and extends previous findings, analysing the FcγRIIa (CD32) polymorphism in relation to the IgG subclass distribution seen among two sympatric tribes living in eastern Sudan, characterized by marked differences in susceptibility to Plasmodium falciparum malaria.Keywords
This publication has 42 references indexed in Scilit:
- Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in MaliMalaria Journal, 2008
- Polymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian populationMalaria Journal, 2008
- Fc gamma Receptor IIa (CD32) Polymorphism and Antibody responses to Asexual Blood‐stage Antigens of Plasmodium falciparum Malaria in Sudanese PatientsScandinavian Journal of Immunology, 2007
- Influence of Carriage of Hemoglobin AS and the Fcγ Receptor IIa–R131Allele on Levels of Immunoglobulin G2 Antibodies toPlasmodium falciparumMerozoite Antigens in Gabonese ChildrenThe Journal of Infectious Diseases, 2005
- A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvantVaccine, 2005
- Fcγ Receptor IIa (CD32) Polymorphism Is Associated with Protection of Infants against High‐DensityPlasmodium falciparumInfection. VII. Asembo Bay Cohort ProjectThe Journal of Infectious Diseases, 2001
- The lower susceptibility to Plasmpdium falciparum malaria of Fulani of Burkina Faso (West Africa) is associated with low frequencies of classic malaria-resistance genesTransactions of the Royal Society of Tropical Medicine and Hygiene, 2001
- Malaria in areas of unstable and seasonal transmission. Lessons from DaraweeshTransactions of the Royal Society of Tropical Medicine and Hygiene, 1998
- Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: Functional role of IgG subclassesResearch in Immunology, 1990
- Dissection of the human antibody response to the malaria antigen Pf155/RESA into epitope specific componentsImmunological Reviews, 1989