Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses.
Authors:
- H WagnerHWH Wagner
- C HardtCHC Hardt
- B T RouseBRB T Rouse
- M RöllinghoffMRM Röllinghoff
- P ScheurichPSP Scheurich
- K PfizenmaierKPK Pfizenmaier
Open Access
- 1 June 1982
- journal article
- research article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 155 (6) , 1876-1881
Abstract
Evidence is presented that interleukin 2 (IL-2) is not sufficient to cause the differentiation of primary cytotoxic T lymphocytes (CTL). Sources of IL-2 were compared for their ability to cause proliferation as well as differentiation into CTL. Whereas all factors caused proliferation, only the crude Con A supernatant had cytotoxic T cell differentiation factor (CTDF) activity. Furthermore, factors absorbed with an IL-2-dependent cell line to remove IL-2 still retained CTDF activity. Thus, IL-2 functions to cause clonal expansion of CTL precursors preactivated by antigen or mitogen, but for their differentiation into CTL, an additional factor is required, here called CTDF.Keywords
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