Hormonothérapie adjuvante après prostatectomie radicale
Author:
- 1 November 2008
- journal article
- research article
- Published by Tech Science Press in Oncologie
- Vol. 10 (11) , 638-640
Abstract
L’analyse de la pièce opératoire après prostatectomie radicale fournit des critères d’agressivité tumorale qui peuvent suggérer que la chirurgie seule n’est pas suffisante pour contrôler la maladie. L’hormonothérapie adjuvante ne trouve sa place que chez les patients présentant un envahissement ganglionnaire, où elle apporte un gain en termes de survie spécifique. Dans les autres cas, ce traitement n’apporte qu’une amélioration de la survie sans progression biologique mais ne permet pas d’améliorer la survie spécifique. Elle ne doit être réservée donc que pour les patients N+. Hormonal treatment combined with radical prostectomy has shown clinical benefits in patients with localized prostate cancer. However, hormone therapy as adjuvant treatment provides significant survival advantages only in patients with lymph nodes involvement. In others, this treatment is associated with an improvement in survival without biochemical progression but it does not improve specific survival. Consequently, the use of adjuvant hormone therapy should be restricted to patients with lymph node invasion.Keywords
This publication has 12 references indexed in Scilit:
- Timing of Androgen Deprivation Therapy and its Impact on Survival After Radical Prostatectomy: A Matched Cohort StudyJournal of Urology, 2008
- Adjuvant Radiotherapy for Pathologically Advanced Prostate CancerJAMA, 2006
- Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomyThe Lancet Oncology, 2006
- Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancerBJU International, 2006
- Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911)The Lancet, 2005
- Is the efficacy of hormonal therapy affected by lymph node status? data from the bicalutamide (Casodex) Early Prostate Cancer programUrology, 2004
- AJCC Cancer Staging Manual2002
- The bicalutamide Early Prostate Cancer ProgramUrologic Oncology: Seminars and Original Investigations, 2001
- Risk of prostate carcinoma death in patients with lymph node metastasisCancer, 2001
- Immediate Hormonal Therapy Compared with Observation after Radical Prostatectomy and Pelvic Lymphadenectomy in Men with Node-Positive Prostate CancerNew England Journal of Medicine, 1999