Temperature-Sensitive Fluorescent Organic Nanoparticles with Aggregation-Induced Emission for Long-Term Cellular Tracing
Authors:
- 20 January 2015
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 7 (5) , 3420-3425
Abstract
Temperature-sensitive organic nanoparticles with AIE effect were assembled in water from tetraphenylethene-based poly(N-isopropylacrylamide) (TPE-PNIPAM), which was synthesized by ATRP using TPE derivative as initiator. The size and fluorescence of TPE-PNIPAM nanoparticles can be tuned by varying the temperature. These nanoparticles can be internalized readily by HeLa cells and can be used as long-term tracer in live cells to be retained for as long as seven passages.Keywords
Funding Information
- Ministry of Education of the People's Republic of China (HUST 2013YGYL003)
- Ministry of Science and Technology of the People's Republic of China (2012CB932500, 2015CB931800)
- Natural Science Foundation of Hubei Province (2013CFB163)
- National Natural Science Foundation of China (20902031, 81372400, J1103514)
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