Angiotensin II activates the human renin promoter in an in vitro model: the role of c-Jun-N-terminal kinase
Authors:
- Attila SebeASAttila Sebe
- Tamás HuszárTHTamás Huszár
- László RosivallLRLászló Rosivall
- István MucsiIMIstván Mucsi
Open Access
- 6 July 2004
- journal article
- Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation
- Vol. 19 (9) , 2184-2191
Abstract
Background. Angiotensin II (Ang II) down-regulates renin expression in juxtaglomerular cells, however, recent experimental evidence obtained in transgenic mice suggested that Ang II may ‘paradoxically’ increase transcriptional activity of the proximal renin promoter.Keywords
This publication has 21 references indexed in Scilit:
- An Abd-B Class HOX·PBX Recognition Sequence Is Required for Expression from the Mouse Ren-1 GeneJournal of Biological Chemistry, 2001
- Angiotensin II-induced Stimulation of p21-activated Kinase and c-Jun NH2-terminal Kinase Is Mediated by Rac1 and NckJournal of Biological Chemistry, 2001
- Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinaseJournal of Biological Chemistry, 2000
- Pathological Expression of Renin and Angiotensin II in the Renal Tubule after Subtotal NephrectomyThe American Journal of Pathology, 1999
- Possible role of c-Jun in transcription of the mouse renin geneKidney International, 1998
- Evidence that renal and chorionic tissues contain similar nuclear binding proteins that recognize the human renin promoterKidney International, 1996
- Renin Regulation in Cultured Proximal Tubular CellsHypertension, 1996
- RENIN mRNA CONCENTRATION IN RAT HYPOTHALAMUS IS DECREASED BY ENALAPRILClinical and Experimental Pharmacology and Physiology, 1995
- Renin expression in renal proximal tubule.Journal of Clinical Investigation, 1993
- Structure, expression, and regulation of the murine renin genes.Hypertension, 1991