The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
Author:
Open Access
- 5 February 2023
- journal article
- review article
- Published by Wiley in FEBS Open Bio
- Vol. 13 (9) , 1548-1557
Abstract
GM1 is one of the main gangliosides of the nervous system, and it exerts neurotrophic and neuroprotective properties in neurons. It is involved in many processes necessary for the correct physiology of neuronal cells. In particular, it is necessary for the activity of neuronal receptors that control processes such as differentiation, survival, and mitochondrial activity. A shortage of GM1 in the substantia nigra is potentially responsible for the neurodegeneration present in Parkinson's disease patients. In this review, I report on the role played by GM1 in neurons and how its genetic shortage may be responsible for the onset of Parkinson's disease.Keywords
This publication has 69 references indexed in Scilit:
- A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patientsJournal of the Neurological Sciences, 2012
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregationNature, 2011
- Impact of receptor clustering on ligand bindingBMC Systems Biology, 2011
- α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in VitroScience, 2010
- Sphingolipids and gangliosides of the nervous system in membrane function and dysfunctionFEBS Letters, 2009
- Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and functionBiochimica et Biophysica Acta (BBA) - Biomembranes, 2009
- Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse HippocampusPLOS ONE, 2008
- Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceProceedings of the National Academy of Sciences, 2007
- Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. WrightJournal of Molecular Biology, 2001
- Formation of a cytosolic ganglioside‐protein complex following administration of photoreactive ganglioside GM1 to human fibroblasts in cultureFEBS Letters, 1990