Direct Synthesis of N‐Acyl Sulfonimidamides and N‐Sulfonimidoyl Amidines from Sulfonimidoyl Azides

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Abstract
Herein, we describe the preparation of sulfonimidoyl azides, and demonstrate their utility in the construction of N‐acyl sulfonimidamides and N‐sulfonimidoyl amidines. N‐Acyl sulfonimidamides were synthesized in good to very good yields via “on water” copper‐catalyzed three‐component coupling between sulfonimidoyl azide, alkynes and water. The use of amines as nucleophiles yielded a wide range of N‐sulfonimidoyl amidines. Both reactions were completed in very short time at room temperature under mild conditions, thus establishing the potential of sulfonimidoyl azides, the aza‐analogues of sulfonyl azides, as an excellent precursor to derive functionalized sulfonimidamides in one step. magnified image
Funding Information
  • DST-INSPIRE (GAP-135739)

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