Good tolerability of high dose colistin-based therapy in patients with haematological malignancies
- 28 March 2017
- journal article
- research article
- Published by Springer Nature in Infection
- Vol. 45 (4) , 505-511
Abstract
Colistin is usually the only drug fully active against multi-drug resistant Gram-negative bacteria, but its nephrotoxicity might limit its use. Recent pharmacokinetic/pharmacodynamic data suggest that high dose of colistin, preceded by a loading dose, are needed to maximize its antibacterial effect. The aim of this study was to determine the safety of high doses colistin, in haematology population.Keywords
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