Laminins: role in invasion, metastasis, and prognosis of malignant neoplasms of various localizations

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Abstract
Laminins are a family of high-molecular-weight heterotrimeric glycoproteins of the extracellular matrix that play a key structural role in basement membranes. Although mutations in intracellular proteins remain the primary drivers of carcinogenesis, the role of changes in the expression and spatial distribution of laminins in the development of malignant neoplasms is gaining increasing importance. Primary focus is given to the patterns of laminin alterations in carcinomas of various localizations, as well as their role in the acquisition of invasive and metastatic potential by tumor cells. Furthermore, the prognostic significance of different laminin isoforms is discussed.

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