WNT10A variants isolated from Japanese patients with congenital tooth agenesis
Open Access
- 9 November 2017
- journal article
- research article
- Published by Springer Nature in Human Genome Variation
- Vol. 4 (1) , hgv201747
Abstract
It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of WNT10A, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signaling.Keywords
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