H ‐ Y ANTIGEN: GENETIC CONTROL OF THE EXPRESSION AS DETECTED BY HOST ‐ VERSUS ‐ GRAFT POPLITEAL LYMPH NODE ENLARGEMENT ASSAY MAPS BETWEEN THE T AND H ‐ 2 COMPLEXES

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Abstract
Low or high expression occurs when the H-Y [Y-linked histocompatibility] antigen on thymocytes of mouse parental strains is weakly or strongly immunogenic, respectively, for F1 hybrids in a host vs. graft popliteal lymph node enlargement assay. Using this assay an attempt was made to locate the genetic factor(s) responsible for the control of H-Y expression within chromosome 17 since previous studies indicated linkage with the H-2 complex. Recombinant from (B10.T .times. C3H/Di)F1 hybrids were produced where crossing over took place between H-2 and T complexes. A gene denoted Hye (for H-Y expression) whose high low alleles originated, respectively, from the B10 and C3H/Di strains was located. In the recombinants, the expression did not follow the H-2 haplotype, but obviously depended on the position of crossing over between H-2 and T. This pointed to the Hye gene mapping proximally from the H-2 complex.

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